Page 655 |
Technology in Australia 1788-1988 |
|||
Table of Contents
Chapter 9 I Introduction II The Australian Chemical Industry III Pharmaceuticals IV Chemists In Other Industries V The Dawn Of Modern Chemical Industry - High Pressure Synthesis VI The Growth Of Synthetic Chemicals - Concentration, Rationalisation And International Links VII Australian Industrial Chemical Research Laboratories i Australian instrument inventions ii Plant protection - overseas and in Australia iii Successes in the laboratory but . . . iv Drugs for sheep and cattle revisited Tetramisole - international success and local manufacture v 'Promicide'* 'Grenade'* to control ticks vi Technical service R&D vii Industry/CSIRO/university collaboration viii Australian entrepreneurs in modern chemistry VIII The Plastics Industry IX The Paint Industry X Acknowledgements References Index Search Help Contact us |
Drugs for sheep and cattle revisited
Tetramisole is a racemate, that is, it consists of two mirror-image isomers otherwise identical (optical isomers) of which only one is biologically active. This is not uncommon in biologicals, but separation of isomers usually involved a series of cystallisations with complementary optically active compounds or complex stereosynthesis. This was just the type of specific challenge in which the late Bob Dewar relished. Once again he postulated stereospecific relationships and 'designed' a few speculative molecules. His colleagues could never quite decide what was scientific vision and what intuition -yet the improbable, almost miraculous happened. He and his 'old faithfuls'[105] found a reagent which produced the desired 1-isomer in high purity and yields of over 90 per cent in a single, extremely simple step. What is more, the useless d-isomer could be converted into the starting material (d,l-tetramisole, the racemate) so that almost quantitative conversion to the active compound was possible. Not only was this elegant and economical, it was technically most valuable, since the racemate tetramisole had a lower safety margin in sheep than some of its competitive products: 1-isomer was doubly safe and fully competitive (Fig. 22).
|
Australian Academy of Technological Sciences and Engineering |